Complexion Imaging: the 7th Generation

This is not like the "7th Generation" of the Star Wars Series. We are talking about the sophisticated  VISIA Complexion Analysis from CANFIELD, who are now in its 7th product iteration.

The renowned company is making a complicated and tricky process (believe it or not, a robust face and complexion image is very tricky to do) into a very user-friendly system.

Standardized images required a very sophisticated imaging methodology, which includes standardized lighting (yes... including polarization and frequencies !!!) and image capture parameters. This is particularly critical when post-imaging image analysis is part of the package. Otherwise...how is is the comparison relevant.

Some of the multiple image post-analysis features offered by the company are very nice, and are relevant in practice. Other are really borderline.... like the "eyelash" analysis. Seriously?? who is ready to pay for this.

Well, we really like the product.
Is this only for cute white caucasian ladies as featured on their website. I would suggest a more diverse view of the market and marketing positioning (or is the product not capable to work on dark or asian skins ?). Hmmmm ?

"SKINSPECTION" – Hybrid Imaging for Skin Diagnosis

The "SKINSPECTION" approach combines two-photon imaging with time-correlated single photon detection, autofluorescence lifetime imaging, high-frequency ultrasound and optoacoustic imaging. 

The innovative combination of these modalities allows to obtain a wide-field view with quantitative depth information of skin lesions and a close-look into particular intra-tissue compartments with quantitative hyperspectral information and subcellular resolution. The goal of the project is to provide a novel unique tool for early diagnosis and treatment control of skin cancer and skin disease. For achieving this objective, two systems for microscopic and macroscopic imaging of lesions were developed in the last 3 years by the partners JenLab GmbH and Imperial College London (two-photon microscopy/FLIM) and Fraunhofer IBMT (Fraunhofer Institute for Biomedical Engineering) and kibero GmbH (optoacoustic/ultrasound imaging). 

The systems were successfully certified for clinical studies and are currently being evaluated for imaging of skin lesions in a bicentric clinical trial at Hammersmith Hospital and Universita di Modena.

Check for the full research project description on the Europe FP7 webportal.

The clinical tomograph MPTflex™ is a novel skin imaging device

(This was announced April 2011... but we missed it...better late than never)

The clinical tomograph MPTflex™, which was developed by the German university spin-off Jenlab GmbH, is a novel skin imaging device that overcomes the poor resolution of skin imaging methods such as ultrasound, optical coherence tomography (OCT) and reflection. ( Note: Do not agree on the comment on OCT... see our blog on the LLTECH Full Field OCT system)

By using two-photon technology, the system's high-resolution skin imaging provides marker-free optical biopsies.

The tomograph is a compact system, with a flexible scan head that includes two detectors for simultaneous measurement of autofluorescence and the second-harmonic generation, used mainly for the early detection of melanoma and diagnostics of dermatological disorders. Providing a fast microscopic view into the skin without any surgery, single cancer cells, as well as elastin fibers and nanoparticles, can be imaged in vivo, and skin aging can be measured. The MPTflex™ tomograph is based on the two-photon effects predicted by the 1963 German-American Nobel Prize laureate Maria Goeppert-Mayer.

The MPTflex™ received the 2011 Prism Award for Photonics Innovation in January. Co-founded in 1999 by Prof. Dr. Karsten König, Jenlab’s primary goals are the development and the establishment of innovative bioinstrumentation based on Femtosecond Laser Technology for biotechnology, cell biology and medicine. More than 2,000 patients have already been investigated at clinics in Irvine, Brisbane, London, Modena, and Berlin. In the U.S., first clinical trials have been conducted at the University of California this year.

JenLab is translating the technology to markets. See the product brochure here and the product picture below. the Product is CE Marked.

Vivascan, by Caliber I.D.

VivaScan is a safe, painless and simple in-office procedure that provides cellular images to enable your doctor to make a diagnosis and decide on treatment. 

With harmless laser light, VivaScan produces clear images of your skin cells that reveal a level of detail that, until now, was only possible with a traditional invasive biopsy. 

Because VivaScan does not damage the skin the way a biopsy does, it can take repeat images of the same area over time. With pain-free skin imaging, precise image quality, and fast results, VivaScan gives you a new level of comfort and confidence when caring for your skin.

The VivaScan® software makes it easy to schedule patients for examinations, perform imaging examinations on one or more lesions during a visit, review, and report on images obtained during an examination. VivaScan® operates each device in the VivaScope® product line. It is used on stand-alone devices, on VivaScope® imaging and reading systems connected by intranet within the same facility, and on systems at different facilities connected by way of the VivaNet® digital telepathology network.

The VivaScan® software is designed to accommodate a wide variety of customer needs, from a solo practitioner to an imaging group with several VivaScope® systems and access to more than one dermatopathologist.

CALIBER I.D. presents a full product line for Skin Imaging / Vivascope systems:

VivaScope® systems offer clinicians and researchers in the fields of medicine and product development the possibility of a real- time, noninvasive optical biopsy of the skin.

VivaScope® 1500 and VivaScope® 3000 systems are FDA 510(k) cleared and have become an integral part of many dermatology clinics and medical institutions for the diagnosis of skin cancers and diseases, and for the evaluation of wound-healing processes and treatment outcomes.

VivaScope® 1500 Multilaser systems are well suited for a wide variety of product development applications for skin care, and have been used by scientists world-wide for the evaluation of cosmeceuticals and pharmaceuticals for more than a decade.

Benefits of VivaScope® Systems:

•Quasi-histologic, cellular imaging comparable to histopathology

•Noninvasive, repeatable imaging; no tissue damage

•Skin tumor diagnosis with high sensitivity and specificity

•Real-time visualization of blood flow and inflammatory processes

•Therapeutic monitoring of the same area of skin over time

•Quantitative data for skin layer thickness and cell sizes

•FDA 510(k) cleared medical imaging technology

3Derm: Engineering undergrads win $100,000 prize for skin imaging device

A team of rising juniors at Yale beat out graduate and undergraduate students from around the country in a national competition to create novel technology for improved healthcare delivery.

Elizabeth Asai, Nick Demas and Elliot Swart won the prize for their development of an early melanoma detection device called a "Stereoscopic Plug-and-Play Dermatoscope and Web Interface." 

Their small, user-friendly, low-cost camera can be used by a doctor or patient to capture and upload 3D pictures to a web-based directory that dermatologists can access to remotely analyze and monitor the topography and volume changes of skin moles.

Next.. they create their company 3Derm:

3Derm combines breakthrough imaging hardware with secure cloud-based software to improve patient outcomes and reduce costs.

Congratulations!

The Focus Camera from EXO Labs: Made for iPad

EXO Labs launches a ruggedized microscope Camera that leverages the iPad platform ( with a "free" App) as a control system and image management tool, targeting the K-12 & Higher Education and Lab needs. This $496 Digital Camera (and App)  is a plug and play accessory to any microscope and iPad device. We think this is highly priced (when compared to an iPad or School Microscope), but that is probably going to go down with adoption and volume.


There is a very little technology gap to bridge and expand to Skin or Wound Imaging, and that is why we wanted to quote this system on our Blog.

In any case.. very cool. Congrats to EXO Labs !!

Wide-field Fluorescent and Darkfield Imaging on a cell-phone

UCLA researchers have developed a matchbox-sized attachment that converts a cell phone's camera into a fluorescent microscope. The device utilizes an inexpensive lens and battery-powered, light-emitting diodes to create a field of view some two orders of magnitude larger than previous cell-phone fluorescent microscopy technology.

It is more than five times smaller than previous cell phone microscopes.

By using side-illumination geometry, the device is also capable of dark-field microscopy on both fluorescent and non-fluorescent specimens, an illumination technique in which only light shown on a biological sample is captured, making it appear as if the sample is on a black background and enhancing the image. The side-illumination technique negates the need for more expensive thin-film interference filters typically used in fluorescent microscopy; an inexpensive plastic color filter can be used for this purpose.

Full publication here, with possible applications in Skin Imaging

Mobile Microscopy: CellScope and iPadScope

At the Fletcher Lab at the University of California, Berkeley, has designed equipment to turn the camera of a standard cell phone into a diagnostic-quality microscope with a magnification of 5x-60x. Cell-phone microscopy enables visualization of samples, followed by capture, organization, and transmission of images critical for diagnosis. This technology is applicable in a wide range of applications beyond diagnostic medicine. The team has developed a suite of devices to image everything from sub-micron bacteria to the surface of the eye.

See” Cell-phone Based Platform for Biomedical Device Development and Education Applications” where “we report the development of two attachments to a commercial cell phone that transform the phone's integrated lens and image sensor into a 350× microscope and visible-light spectrometer. The microscope is capable of transmission and polarized microscopy modes and is shown to have 1.5 micron resolution and a usable field-of-view of 150×150 microns^2 with no image processing, and approximately 350×350 microns^2 when post-processing is applied. “