Light-CT™ uses white light to scan beneath the surface
of tissue. It does not require any tissue preparation, modification, or staining
of any kind. Images are provided within minutes thanks to a non-destructive
process, whereas histology (the current Gold Standard) takes several hours or
days, and requires an actual slicing of the sample. The images offer a cellular
resolution of 1 µm in all 3 dimensions. 3D views can be reconstructed and
displayed using a standard DICOM viewer.
Light-CT™ technology produces high quality images that
are comparable to histology.
The Light-CT™ scanner is an automated system.
Image acquisition and calibration are automatic. Light-CT™ captures “en face”
images directly using a megapixel camera and a pair of microscope objectives.
Light-CT™ derives from low coherence interference microscopy. The
interferometer can be displaced to step the focal plane through different
depths beneath the surface to create a 3D tomographic image. “En face” capture
allows Light-CT™ to operate with high lateral resolution (typically ~1µm) using
medium or large aperture microscope objectives. An incoherent light source
illuminates the whole field of the microscope objectives. Due to the low
temporal coherence of the source, interference occurs only when the optical
path lengths of the two arms of the interferometer are identical within 1µm. When
a biological sample is placed under the microscope objective in the sample arm,
the light reflected by the reference mirror interferes with the light reflected
or backscattered by the sample structures contained in a limited volume. Real
time signal processing is applied during depth exploration of the sample. The
image stack is thereby optimized to allow 3D imaging.
Purpose of device: digital imaging of tissue
microstructure including the border between the stratum corneum and the
epidermis
Main application: medical practices
Price range: $120-$150,000
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