"SKINSPECTION" – Hybrid Imaging for Skin Diagnosis

The "SKINSPECTION" approach combines two-photon imaging with time-correlated single photon detection, autofluorescence lifetime imaging, high-frequency ultrasound and optoacoustic imaging. 

The innovative combination of these modalities allows to obtain a wide-field view with quantitative depth information of skin lesions and a close-look into particular intra-tissue compartments with quantitative hyperspectral information and subcellular resolution. The goal of the project is to provide a novel unique tool for early diagnosis and treatment control of skin cancer and skin disease. For achieving this objective, two systems for microscopic and macroscopic imaging of lesions were developed in the last 3 years by the partners JenLab GmbH and Imperial College London (two-photon microscopy/FLIM) and Fraunhofer IBMT (Fraunhofer Institute for Biomedical Engineering) and kibero GmbH (optoacoustic/ultrasound imaging). 

The systems were successfully certified for clinical studies and are currently being evaluated for imaging of skin lesions in a bicentric clinical trial at Hammersmith Hospital and Universita di Modena.

Check for the full research project description on the Europe FP7 webportal.

How Skin Coloration arises

Sometimes it is good to recall the fundamentals: he skin consists of a number of layers with distinct function and distinct optical properties. 

White light shone onto the skin penetrates superficial skin layers and whilst some of it is absorbed, much is remitted back and can be registered by a camera.

The key to the interpretation of image colors in terms of the underlying histological parameters is a model of tissue coloration which provides a cross-reference between the colour and the histology. 

Here is a model discussed ( Weblink)

This model is constructed by computing the spectral composition of light remitted from the skin given parameters specifying its structure and optical properties. This step needs to be carried out only once. As the mapping between the colours and the parameters is unique for the skin, each colour corresponds to one specific set of histological parameters.

The model of normal skin coloration is representative of all the normal skins, irrespective of racial origin, age or gender. The structure remains the same, and the only differences are in the magnitudes of the parameters.

Abnormal skin coloration

The model above has been constructed for skin which has a normal structure. Skin coloration associated with abnormal conditions does not necessarily have to conform to this model.

Cool: BASF Skin Care Forum !

BASF hosts a blog on Skin Care, with articles that are well done, covering a wide spectrum of topics ranging from Skin, Air care to regulatory and Toxicology matters. 

Very well done, and we recommend a few specific recent articles:

"Geriatric Dermatology" , June 2014 by Christos Zouboulis

"Male Skin Care in the U.S. Markets", June 2014 by Zoe Draelos

"Trends in Home Care Devices," Feb 2014 by Imogen Matthews.

Now ... a search on "personalized" yields nothing... hummm perhaps we should team up there.

EMAGE Advanced Skin Imaging

The EMAGE Advanced Skin Imaging system is an Advanced, all-digital Triple Spectral Skin Analysis which allows Aesthetica Medical Spa estheticians to view and report our client’s pore and wrinkle depth, pigmentation, and vascularity, texture, porphyrin and sebum, and more, all with incredible accuracy.

Intense magnification using a 16-megapixel-imaging array reveals extensive detail, making recommendations for laser resurfacing, microdermabrasion, neurotoxins, fillers and cosmeceuticals simple and easy to explain.

With the EMAGE you can

• Examine targeted areas under intense magnification in normal, polarized, and UV light
• Create multiple, high-quality views of the face
• Map, measure and analyze fine lines, pigmentation, and vascularity
• Evaluate skin tone and texture
• Helps suggest comprehensive services/products available at Aesthetica Medical Spa and Laser Center
• Uncovers future problem areas
• Provides consistent, comparative analysis which helps Aesthetica estheticians and practitioners to track treatment effectiveness.

More on the manufacturer Website, including a Free Trial.

Magic Ring Skin Analysis Test Machine

We are pleased to quote the recent article from "Future Ready Singapore" that showcases four Skincare Innovations for Asian women, including one specific image-based Skin Analysis tool: 

" Asian women boast a wide range of complexions and skin textures. Premium skincare brand SK-II invented the Magic Ring Skin Analysis Test Machine to provide tailor-made skincare counselling, leveraging US consumer product giant P&G’s extensive research into skin science. 

Invented in Japan, the device takes a high-resolution picture of the skin and then analyses skin conditions in areas such as texture, firmness, wrinkles, radiance and spots. 

Based on the results, the beauty advisor then suggests a personalised skincare treatment regime."

April 16th , 2014: Nice review on INSTYLES. See here

January 2013 : First Bloggers Workshop in Singapore. See Here.

The Focus Camera from EXO Labs: Made for iPad

EXO Labs launches a ruggedized microscope Camera that leverages the iPad platform ( with a "free" App) as a control system and image management tool, targeting the K-12 & Higher Education and Lab needs. This $496 Digital Camera (and App)  is a plug and play accessory to any microscope and iPad device. We think this is highly priced (when compared to an iPad or School Microscope), but that is probably going to go down with adoption and volume.


There is a very little technology gap to bridge and expand to Skin or Wound Imaging, and that is why we wanted to quote this system on our Blog.

In any case.. very cool. Congrats to EXO Labs !!

DermaCompare: "designed to revolutionize the process of diagnosing melanoma" (...Really ?)

Out of Israel, DermaCompare, a market-centric spin off from Esmeral Medical, is promoting a Cloud-based sophisticated image processing technology fro skin imaging. The skin lesions detection software solution is designed to revolutionize the process of diagnosing  melanoma, the major cause of skin cancer related mortality. 

DermaCompare supports early stage diagnosis of skin cancer by providing constant monitoring of suspicious skin lesions using various  imaging methods, thereby significantly increasing the chances of treating the condition, as well as lowering the cost and complexity of treatment.


The product is not FDA approved and detailed information / case studies / performance of the system is not very accessible. We would love to know more ( leave a comment).

Their YouTube clip provides some fuzzy screen captures, some insights on the technology platform ( " we use aerial defense technology to save 420 million people from skin cancer") but does not discuss clinical efficacy nor business models. 

Announcing the 2014 and Third Edition of The International Dermatology Institute (IDI) Technology Forum on June 10th 2014

DermaNest, and TRI/Princeton jointly announce the 2014 and Third Edition of the  International Dermatology Institute Technical Forum on Tuesday June 10^th 2014, 3 – 6 pm, on the TRI/Princeton Campus

The Technical Forums at the International Dermatology Institute offer Technology-based companies an unique opportunity to showcase their latest solution to a selected panel of industry leaders seeking for new technologies in the field (e.g. R&D Department leaders, Product Portfolio Managers, Innovation scouts of large international companies)

Participants will have the opportunity to present their solutions (45 mins presentation and product demonstration) during a highly interactive and intimate format. The three-hour event will only be offered to a limited number of companies and followed by a networking reception and product demonstration. Company representatives will have the opportunity of making quality contact with companies such as P&G , Johnson and Johnson, Ashland, Colgate…

The International Dermatology Institute (IDI) offers dermatology focused start-up companies from around the world the opportunity to effectively advance their business, especially in the US.   By leveraging the services of DermaNest and the TRI Center for Skin Science and Applied Dermatology, small companies can locate themselves within and receive services from IDI on the Princeton, NJ based TRI Campus. The Princeton area is the heart of the largest pharmaceutical, biotech, drug discovery and life-sciences ecosystem in the world, and also includes the headquarters and laboratories of many world class skin care, cosmeticeutical and wound-care companies.

TRI and DermaNest share the common mission of aiding organizations in the development of personalized dermatology and cosmetics by providing technical solutions that include predictive diagnostics, imaging devices and therapeutic methods for the advanced dermatological, cosmetic, and wound care markets. To learn more about the IDI Model, please visit TRI’s website.

TRI Princeton is a non-profit research Institute dedicated to Research, Education and Service in advanced industries for more than 80 years and is a recognized authority in cosmetic science.  TRI provides technical innovation, research and claim support to the cosmetic and dermatology industries in addition to hosting various educational forums for professional scientists, including annual international conferences.  TRI’s Center for Skin Science and Advanced Dermatology specializes in the study of skin’s structure, behavior and variability with the goal of a more personalized approach to skin protection and repair based on genetic predisposition and variations occurring from age, disease and environmental impact. 

DermaNest develops the business of International Personalized Cosmetics and Skin-Care Solutions and Services for the US Markets. Personalized Solutions include Predictive Diagnostics, Therapies and Companion Diagnostics, for the Cosmetic, Cosmeceuticals and Wound Care markets. DermaNest's business model and highly experienced team empower early stage companies to play in high growth market segments, at a fraction of the cost of alternative solutions.